iMRMC - Multi-Reader, Multi-Case Analysis Methods (ROC, Agreement, and
Other Metrics)
This software does Multi-Reader, Multi-Case (MRMC)
analyses of data from imaging studies where clinicians
(readers) evaluate patient images (cases). What does this mean?
... Many imaging studies are designed so that every reader
reads every case in all modalities, a fully-crossed study. In
this case, the data is cross-correlated, and we consider the
readers and cases to be cross-correlated random effects. An
MRMC analysis accounts for the variability and correlations
from the readers and cases when estimating variances,
confidence intervals, and p-values. The functions in this
package can treat arbitrary study designs and studies with
missing data, not just fully-crossed study designs. An overview
of this software, including references presenting details on
the methods, can be found here:
<https://www.fda.gov/medical-devices/science-and-research-medical-devices/imrmc-software-do-multi-reader-multi-case-statistical-analysis-reader-studies>.
